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The Ultimate Guide to Colorado’s Natural Medicine Health Act (SB23-290 Psychedelics Law)

By Joshua Kappel, Juliana Todeschi, George Winfrey, Will Denney
Aug 22, 2025

Colorado’s groundbreaking psychedelics law, the Natural Medicine Health Act (SB23-290), continues to take shape. Originally signed into law in 2023, the Act established the country’s most comprehensive framework for natural psychedelic medicine. Since then, Colorado regulators have finalized rules for facilitator licensing, healing centers, cultivators, and testing facilities, with the program officially launching on January 1, 2025. This updated guide reflects the latest regulatory developments, including compliance requirements, Indigenous inclusion, and public health protections.

Colorado Marijuana Rulemaking Is Underway

By Genevieve Meehan
Jul 24, 2023

The 2023 rulemaking process will run through the fall and address a wide range of topics, including marijuana cultivation, manufacturing, and testing standards; fee increases; regulatory efficiency; implementation of legislation enacted earlier this year; intoxicating hemp; and hospitality.