The Ultimate Guide to Colorado’s Natural Medicine Health Act (SB23-290 Psychedelics Law)
By Joshua Kappel, Juliana Todeschi, George Winfrey, Will Denney
Aug 22, 2025
Colorado’s groundbreaking psychedelics law, the Natural Medicine Health Act (SB23-290), continues to take shape. Originally signed into law in 2023, the Act established the country’s most comprehensive framework for natural psychedelic medicine. Since then, Colorado regulators have finalized rules for facilitator licensing, healing centers, cultivators, and testing facilities, with the program officially launching on January 1, 2025. This updated guide reflects the latest regulatory developments, including compliance requirements, Indigenous inclusion, and public health protections.